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Any prolonged caloric deficit puts muscle at risk

Psychiatry 14 , 1238353 (2023)

In these studies, single administrations of long-acting hydrogel-based therapies of Sema or TZP were similarly effective at regulating blood glucose and weight compared to daily injections of either Sema or TZP in standard aqueous vehicles

Interfering with their use of it (through drugs called glutaminase inhibitors) could be a potential treatment approach

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But knowing why they happen gives you the power to manage them effectively rather than just suffering through them