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Because TBK1 is an essential autophagy-related protein which phosphorylate autophagy receptors (i.e., autophagic adaptor optineurin) to regulate the recruitment of cargo into autophagosomes (Weidberg and Elazar, 2011), it is possible that ICP34.5 could also indirectly inhibit autophagy by modulating TBK1 signaling

Acetic Acid More unstable peptides are often reconstituted using dilute acetic acid solutions, typically between 1-30%

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9b, quantification at the tumor: Fig

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