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10.2174/1381612824666180608101119 18 SikiricP.SeiwerthS.GrabarevicZ.RucmanR.PetekM.RotkvIcI.et al (1993)

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The rats were euthanized, and tissue samples (brain, heart, kidneys, liver, spleen, lung, stomach, intestine, muscle, grease, ovaries, womb, testicles, and thymus) were collected at 3 min, 10 min, 1 h, and 24 h after administration (three males and three females at each time point)

It is important to note that in instances where stenosis is so severe that the patient has lost circulation to the legs or bladder control a surgical consult should be made immediately

This gentle approach prevents foaming, which creates air-liquid interfaces where peptides denature and aggregate irreversibly