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389 In contrast, for patients with nonresectable, advanced, or metastatic ESCC, the POWER trial, a phase III study of cisplatin and 5-fluorouracil with or without the monoclonal antibody panitumumab, was stopped early owing to a lack of efficacy in the panitumumab arm, indicating that EGFR inhibition with panitumumab did not improve survival in this unselected advanced ESCC population

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Similarly, PRR11i increases LPO and disrupts the mitochondrial morphology regulated by DHODH, thereby promoting ferroptosis in GBM cells and enhancing their chemosensitivity to temozolomide (TMZ)[42]

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