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Off-label use in non-HIV populations relies on extrapolation, not large RCTs
Available in both injectable and oral forms, Semaglutide is known for its ability to regulate blood sugar levels and appetite
Cotgreave IA, Moldeus P
If it is not, replace it
In rare cases, it can cause kidney or gallbladder issues, inflammation of the pancreas or sudden changes in vision requiring prompt medical attention
This is mechanistically different from dieting: dietary restriction alone triggers compensatory hormonal responses (elevated ghrelin, suppressed leptin, reduced NEAT by 200400 calories/day) that work against weight loss over time
