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Semaglutide is a medication that mimics the hormone GLP-1 (glucagon-like peptide-1)

Long-Term Weight Loss: Unlike quick fixes, semaglutide promotes a consistent and sustainable weight loss journey that can last for months

Other medications like Kerendia (finerenone) that do not lower glucose are sometimes included as adjunctive therapies, too

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In the tirzepatide SURMOUNT-4 trial, participants regained approximately 14% of their original body weight within one year of stopping, while those who continued tirzepatide lost an additional 5.5%

Pivotal Phase 3 trials Trial SURMOUNT-1 (NEJM 2022) Population 2,539 adults, obesity, no diabetes