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In pancreatic cancer, the ACSS2-mediated Zrt- and Irt-like protein 4 (ZIP4) signaling pathway reshapes metabolic activity by increasing the macropinocytosis of cancer cells and is positively associated with a poor prognosis [207]
N.SpechtJ
Javanmardi Z, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Shapouri-Moghaddam A, Ahmadi P, Mollazadeh S, Tabasi NS, Esmaeili SA (2024) Tolerogenic probiotics Lactobacillus delbrueckii and Lactobacillus rhamnosus promote anti-inflammatory profile of macrophages-derived monocytes of newly diagnosed patients with systemic lupus erythematosus
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i.e., they were not necessarily acting primarily as antioxidative enzymes
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