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CircHIPK3 is one of the most abundant circRNAs in -cells and regulates hyperglycemia and IR by sequestering miR-124-3p and miR-338-3p, thereby increasing mRNA expression of key -cell genes (e.g., Slc2a2 , Akt1 , and Mtpn ), insulin secretion, and -cell proliferation

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After acute brain injury, the activation of oxidative stress and inflammatory reactions results in the buildup of intracellular iron, subsequently triggering ferroptosis (Shen et al., 2020)

We hope that in the future, more researchers will focus on more basic research on HO-1 in DN, including its expression regulation, mechanism of action, and interaction with other molecules

Erectile dysfunction (ED) often coexists with T2D and obesity

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