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Karolinska Instituet Research Summary: The main results are: Three days treatment with codeine increase the serum total testosterone levels, whereas LH and FSH are unaffected In one of the participant a 3 days codeine use increased the T/E ratio above the individual threshold in ABP The administration of 500 and 125 mg testosterone enanthate were detected in all study subjects when three baseline T/E values were added to the ABP and the co-administration of codeine did not conceal the results One of the participants showed a high morphine/codeine ratio post codeine treatment, indicating that discriminating between morphine and codeine use could be difficult There were no association between UGT2B7*2 polymorphism and urinary concentrations of morphine and codeine glucuronides Funded: 2016 Principal Investigator: Dr

Lippincott Williams and Wilkins, New York, 1999, pp

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