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It plays a vital role in protecting tissues from oxidative stress and supporting the body's natural detoxification pathways
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Traditional proteomics-based methods, such as N-terminomics 37,38,39 and proteomic identification of protease cleavage sites 40 , are well suited for global analyses of protease activity but can be low throughput and may lack the sensitivity to detect low-frequency, yet biologically perturbative, off-target cleavage events
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At the same time, glutathioneoften called the bodys master antioxidantnaturally declines over time
Incretin-based therapies, including glucagon-like peptide-1 receptor agonists (GLP-1RAs) and dual glucose-dependent insulinotropicGLP-1RAs, have evolved from metabolic therapies to agents with either proven or potential protective effects on the kidney and heart
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