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The SELECT data simply quantifies the long-term clinical benefit of those early changes sustained over time

The activation of these events results in an increase in vasoconstriction and the promotion of thrombus formation, which can ultimately lead to the development of atherosclerosis (16)

Neutral buffered formalin was used for 24 h to fix the cardiac tissue, after fixation dehydration was performed with a series of upscale alcohol solutions and the tissue was embedded in paraffin