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Semaglutide is a GLP-1 receptor agonist that works by mimicking a naturally occurring hormone involved in appetite regulation, gastric emptying, and blood sugar control

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Over-loss and muscle pooled SURMOUNT-1 through -4 analysis found BMI below 22 in 7.26% of tirzepatide-treated participants

While the active ingredient remains the same, factors like dosage, purity, and individual response can influence outcomes

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This step aimed to reduce the masking effect of gastrointestinal events to avoid possible competitive bias