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Mitochondrial energy metabolism disorders, such as decreased TCA cycle enzyme activity, impaired respiratory chain function, reduced ATP production, and increased free radical and ROS levels, support the mitochondrial cascade hypothesis in AD pathogenesis
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Subsequently, since the 1920s, it was observed that an adverse side effect of 8-aminoquinolines (primaquine and plasmoquine), used for the treatment and the prophylaxis of malaria, was AHA