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Epithalamin levels decline with age, corresponding with the age-related decline in cellular regenerative capacity and melatonin production
Patients noticing fine lines or crows feet
Maeda E, Murata K, Kumazawa Y, et al
Aug 2020;24(15):7946-7952
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Given the heterogeneity in CRSwNP immunopathology, recent research has categorized the condition into endotypes based on distinct immune responses [26, 27]: Type 1 (Th1-mediated, often associated with neutrophilic inflammation and IFN-), Type 2 (Th2-mediated, characterized by eosinophilic inflammation and elevated IL-4, IL-5, and IL-13), and Type 3 (Th17-mediated, related to IL-17 and neutrophil predominance)
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