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The therapeutic utility of native GLP-1 is limited by its rapid degradation [2], primarily mediated by dipeptidyl peptidase-4 (DPP-4) and secondarily by neutral endopeptidases (NEPs) and renal clearance [3, 4]
References: Gindri IM, Ferrari G, Pinto LPS, Bicca J, Santos IKD, Dallacosta D, Roesler CRDM
10.1007/s10541-005-0104-5 Biochemistry ( Mosc
doi:10.1111/cen.13828 Witchel SF, Teede HJ, Pea AS
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