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We can now confidently say we have a drug that matches bariatric surgery outcomes

There are many proposed mechanisms by which a drug or reactive metabolite alters a self-protein and activate T cells

Of note, incidence of MTC was extremely low in all of the large cardiovascular outcome trials with no significant increase seen in GLP-1RA-treated individuals, although it should be highlighted that some of the trials did have a family history of MEN-2 as an exclusion criterion

There's no good evidence that short-term use does anything measurable

I grew up with fond memories of the joy of a McDonalds Happy Meal

Dose, tolerance, digestion, food, and product type all matter