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A group at the Walter Reed Army Institute of Research (WRAIR) created prefusion-stabilized S-trimer-ferritin nanoparticles (SpFNs) , which were shown to be stable candidate immunogens that elicited potent nAb titers against SARS-CoV-2 variants and robust protection against challenge in a K18-hACE2 mouse model [128, 129] (Table 3)
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There are also helpful guides you can use such as the infusion/injection decision tree
A vitamin B12 deficiency may be the cause
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