once-weekly semaglutide in adults with overweight or obesity once a week obesity, with or without type 2 diabetes in an east Asian population (STEP 6): a randomised, double-blind, double-dummy, placebo-controlled, phase 3a trial Adults with overweight or obesity

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Article written by: Doris Munoz-Mantilla, MD, FOMA, DABOM Article reviewed by: Anila Chadha MD, DABOM Family physician and Obesity Medicine physician at Dignity Health Medical Group, Bakersfield, California

Postprandially, levels of GLP-1 (737) are low compared to GLP-1 (736), hence the error of using an amidation-specific assay is small when measuring postprandial samples (20)

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Beginning at a lower dose reduces the likelihood of nausea, vomiting, and gastrointestinal discomfortside effects that can derail adherence in the first two to four weeks of treatment

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