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Diabetes 61 , 4048 (2012)
After completion, as monitored by UPLC and ESI-LCMS, the reaction mixture was diluted with buffer A, filtered and purified directly by preparative RP-HPLC, eluting with a linear gradient (see the Peptide cleavage and purification section)
In the pancreas, GLP-1 receptor agonists enhance glucose-dependent insulin secretion whilst suppressing inappropriate glucagon release, thereby improving glycaemic control
In this 2 years prospective study, the researchers found that liraglutide monotherapy did not affect the patients total bone mineral density (Zhang et al., 2018)
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