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The ACG IBS guideline conditionally recommends against probiotics for global IBS symptoms

The onset is 5 to 15 minutes, peak action occurs at 45 to 75 minutes, and duration is 2 to 4 hours

doi: 10.1016/j.metop.2024.100283 22 WildingJPHBatterhamRLDaviesMVan GaalLFKandlerKKonakliKet al

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However, if bruising is severe, spreads rapidly, or is accompanied by warmth, redness beyond the site, or drainage, contact your provider immediatelythese signs may indicate infection or a bleeding disorder requiring evaluation