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both have high energy demands due to continuous activitycardiomyocytes for rhythmic contractions and neurons for electrical and chemical signalingand are post-mitotic, making them reliant on mitochondrial quality control as they cannot replace damaged mitochondria through cell division
DSIP, if effective, would layer on deeper slow-wave support rather than replace these staples
External and iatrogenic causes: Excessive supplementation: High-dose oral supplements or frequent intramuscular injections (hydroxocobalamin or cyanocobalamin) can elevate serum levels, though this rarely causes problems
The FEBS Journal
PMID 17403968
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