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Notable modifications of MT1 over alpha-MSH include the substitution of methionine and L-phenylalanine at the fourth and seventh positions with norleucine and D-phenylalanine, respectively
Furthermore, researchers were unable to identify the DSIP gene, a precursor protein, or a specific receptor for the peptide
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Altogether, these findings support the so-called melatonin-estrogen hypothesis of breast carcinogenesis 24
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