It is therefore likely that these drugs will succeed in counteracting the physiological adaptations normally caused by weight loss (increased appetite, in particular), but that these adaptations quickly take over after stopping the medication and promote the return to the initial overweight, before treatment
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CREB, cyclic AMP response element-binding protein
HUM delivers 10 g of Fibersol-2, matching the dose that raised postprandial GLP-1 by roughly 40% in trial conditions
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While the first phase is rapid and triggered by glucose in the blood, the later, second phase is longer and slower and not dependant on blood sugar