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As these patients were most likely classified as moderate progressors, the results suggested that 50 mg methylcobalamin injections could be beneficial for patients with ALS in the early stage and with moderate progression rate, the researchers wrote

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Thus, there is a strong link between mitochondrial dysfunction and the pathogenesis of a wide range of human diseases involving multiple systems, encompassing neurological disorders, cardiovascular diseases, liver diseases, renal dysfunction, diabetes mellitus, and malignancies associated with DNA damage response (Harrington et al