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This study paved the way for further research on the extrinsic apoptotic pathway
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Liver regeneration after acetaminophen hepatotoxicity: mechanisms and therapeutic opportunities
GBA crosstalk occurs via multiple channels, with rapid neuronal signaling primarily by the vagus nerve, as well as the gut connectome (via the semi-autonomous ENS), with more delayed feedback being achieved through neuroendocrine and neuroimmune signals into the circulation [351, 506] in the form of gut-derived neurotransmitters (dopamine (DA), serotonin (5-HT), GABA, and histamine), hormones, and inflammatory mediators (i.e., cytokines)
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