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[11] In US regulatory terms, both are unapproved research chemicals, not therapeutics, and neither carries the safety, efficacy, or manufacturing assurances that approval would represent

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Nat Clin Pract Endocrinol Metab 2:395407 Savage MO, Underwood L, Yordam N, Yuksel B, Smith A, Attie K, Camacho Hubner C (2006b) Treatment of short stature in children with severe primary IGF-I deficiency with once daily rhIGF-I/rhIGFBP-3 administration [abstract CF1-100]