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Methods A retrospective cohort study was conducted using the US Collaborative Network in patients with IBD on TZP between January 5, 2022 and December 31, 2023

Musculoskeletal factors unrelated to medication: Type 2 diabetes itself is associated with increased prevalence of musculoskeletal conditions, including back pain, due to factors such as diabetic neuropathy, reduced physical activity, obesity, and inflammatory processes

Gastrointestinal side effects are the most common early experiences, with nausea affecting approximately 30-40% of patients during dose initiation and escalation, varying by dose level

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