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The standard pharmacological rule of thumb is that after four half-lives about 94% has been eliminated and after five about 97%, which is why five half-lives is the conventional shorthand for "substantially cleared." Two caveats matter immediately

doi: 10.1016/j.avsg.2010.02.018

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Results are more gradual than those associated with anabolic steroids, but many patients prefer this approach because it works with the bodys natural signaling pathways rather than overriding them

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These effects often persist as long as the medication is taken