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The levels of overall tyrosine phosphorylation in these cells were unaffected by JMF4073 treatment (Fig

For the most of the commonly used drugs, the hypoxic TME rich in HIF-1 plays a major role in the development of drug resistance through multiple pathways [3,18-32]

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GHK-Cu peptide is used for four main goals

This process, along with GCL inhibition and the formation of mixed disulfides between GSH and protein sulfhydryl, concurred to a steady-state decrement of free GSH concentration and, consequently, to an intracellular redox state shift toward more oxidizing conditions, which could be required for avoiding fast reduction of oxidized cysteines allowing the upstream ROS-induced autophagic stimulus to be propagated

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