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2015;7(Suppl 2):S554-558

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The discovery of the incretin hormone GLP-1 and its subsequent studies led to a better understanding of its role in glycemic control and body weight regulation, as well as its potential use in clinical settings

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The substitution at position 2 is the functionally important one: it blocks cleavage by dipeptidyl peptidase-4, the protease that degrades native GRF within minutes

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