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To respond to antigen signals and cytokines, the upregulation of amino acid transporters is used to meet the demand for the supply of large neutral amino acids in activating immune cells (Sinclair et al., 2013)

Plant Cell Environ 34(1):2132

Also, recent evidence suggests that GSH plays a crucial role in the control of epigenetic mechanisms 3,4,28,29,30,31 either independently or by redox phenomenon

Glutathione in dermatology: a bright future or fading hype

Oxidized glutathione stimulates the formation of disulfide bonds between adjacent thiol groups in the protein molecule and changes their properties: GSSG + Pt-(SH)2 Pt(S-S) + 2GSH, and also interacts with SH-groups of proteins and forms "mixed disulfides", which changes the properties of proteins, causing dysfunction of cells

Unfortunately, these study designs proved to be unsuccessful due in part to the excitotoxicity effect of NAC