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It is a synthetic peptide analogue of amylin, a hormone involved in regulating energy intake and metabolic processes
Barrea L, Verde L, Camajani E, Cernea S, Frias-Toral E, Lamabadusuriya D et al (2023) Ketogenic diet as medical prescription in women with polycystic ovary syndrome (PCOS)
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Interestingly, this process was mediated by TLR3 recruitment to the metabolic checkpoint kinase complex mTORC2, which induces chemokine production and TLR3 trafficking to the cell periphery thanks to the RAb7 GTPase, a protein involved in intracellular traffic processes (Sato et al., 2018)
Considering short half-life of native GLP-2 in human circulation and promising results of teduglutide, which half-life is modestly extended to 35 h, current research focuses on an increase of the time of GLP-2 action by developing new, more stable, GLP-2 analogs
What the evidence covers today (and what's still missing) The weight-loss conversation would be easier if we had large, controlled human trials measuring fat-loss outcomes
