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GSH accounts for about 95% of the total non-protein thiols within cells, with intracellular concentrations ranging from 0.5 to 10 mM, far surpassing the levels of free cysteine (3-4)

Hepatic Detoxification via Glutathione-S-Transferases In hepatocytesthe primary site of xenobiotic metabolismglutathione (GSH) conjugates electrophilic toxins via glutathione-S-transferases (GSTs), enhancing their solubility to facilitate elimination through bile or urine (26)