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It adds incretin, GH-axis, and mitochondrial pathways at the same time, which increases uncertainty and makes it harder to identify the cause of any result or side effect

This is further confounded by the fact that NRF2 target genes regulate almost all aspects of maintaining protein, redox, and metabolic homeostasis, as well as epigenetic regulators and other transcription factors

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Thalidomide, which also has TNF- suppressive properties, should not be used because a clinical trial was stopped early owing to increased mortality [57]

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