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Then, HIF-1 can induce lactate production, disrupt TCA cycling, and upregulate IL-1 expression (123, 124)

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If a target compound is present above a threshold concentration, the antibody binds to it and triggers a detectable signal

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204 Similarly, administration of the PRMT5 inhibitor PJ-68 in a CML mouse model with high expression of PRMT5 LSCs could deplete DVL3, thereby inhibiting Wnt/-catenin signaling and significantly prolonging the survival time of a retroviral BCR-ABL-driven CML mouse model