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Regul Pept (2014) 190-191:111

Above that threshold, additional methionine or choline doesn't compound the effect because the liver's methylation enzyme capacity is saturated

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Krafft et al., 2017)

Common reconstitution errors that cause reactions: Over-agitation: Shaking the vial vigorously creates foam and can denature the peptide, producing aggregated protein fragments that trigger stronger immune responses