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FIGURE 2 FIGURE 3 Fatty Acid Metabolism, Carnitine and Cancer The carnitine supply is conditio sine qua non to carry out the -oxidation of fatty acids by mitochondria
pharmacodynamic overlap possible via shared antioxidant pathways Primary concern / IV glutathione and liver-enzyme monitoring in patients on dulaglutide Monitoring recommended / LFTs at baseline and periodically when adding high-dose IV glutathione Evidence gap / no randomized controlled trial has tested the combination directly GLP-1 antioxidant effect / dulaglutide independently reduces oxidative stress markers in human studies Key guideline / ADA Standards of Care 2024 does not list glutathione as contraindicated with GLP-1 agents Bottom line / low-dose oral glutathione appears safe
Most of the known selenoproteins are expressed in the thyroid gland, including some with still unknown functions
Some are approved for type 2 diabetes
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These enhancements were speculated to be a direct effect of liraglutide, rather than an effect of decreased blood glucose, which was achieved by dapagliflozin and acarbose [91]
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