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In addition, G protein-coupled excitatory GLP-1 receptors are located in central regions subserving disparate brain functions (eg, ventral tegmental area, nucleus accumbens, hippocampus, lateral septum, hypothalamus)

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On the biological level, changes in fluid biomarkers, inflammatory markers, SCFA levels, and intestinal permeability markers can offer mechanistic insights and contribute to elucidating pathophysiology (109)