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While constipation is a common side effect of GLP-1s, some patients with IBS, bloating, diarrhea, or irregular digestion notice that their symptoms actually improve while on the medication

This report describes opposing effects of synaptic compared with extrasynaptic NMDARs on BDNF expression and cell survival: the activation of synaptic NMDARs led to upregulation of BDNF expression and the activation of extra-synaptic NMDARs reduced BDNF expression

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There are real biological reasons GLP-1 drugs could help with neurodegeneration and mental ill-health

The dose is then increased to 0.5 mg once weekly

Kharb, S