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In addition, lysine demethylase 4C (KDM4C) can also increase the expression of SSP genes by directly demethylating the promoter of SSP genes or ATF4, a transcriptional substrate of NRF2 (Denicola et al., 2015

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As discussed previously, this was speculated to be caused by the interruption of the gliotoxin biosynthetic pathway directly following the incorporation of GSH, resulting in a GSH sink. Thus, we propose that gliotoxin and EGT biosynthesis are interlinked, with a possible involvement of GSH, which infers that A

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Paolo Di Bartolo

Patent # 6,703,042 B1