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Therefore, PEN2 plays a key role in the mechanism by which metformin enhances GLP-1 secretion

Long-acting Injectable GLP-1 receptor agonists for the treatment of adults with type 2 diabetes: Perspectives from clinical practice

This triple-action mechanism distinguishes retatrutide from existing approved therapies such as semaglutide (a GLP-1 receptor agonist) or tirzepatide (a dual GIP/GLP-1 receptor agonist), though no head-to-head clinical outcome trials comparing these agents have yet been published

She explained that she had always been a habitual snacker, but with GLP-1 support, that urge was gone

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