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This can provoke local irritation or immune reactions

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Cho BC, Han JY, Kim SW, Lee KH, Cho EK, Lee YG, et al

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In that study, the glucose-sensing transcription factor carbohydrate response element binding protein (ChREBP) has been shown to initiate a regulatory program driving an early transcriptional activation of metabolic genes, which is followed by a second wave of transcriptional regulation wherein cell-cycle genes are activated and -cell identity genes are repressed

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