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Hormones, insulin resistance, metabolism, sleep, stress, medications, thyroid disorders, and other medical conditions can all contribute to difficulty losing weight

Lixisenatide and beinaglutide Lixisenatide and beinaglutide, including EX-BID as discussed earlier, are classified as short-acting GLP-1RAs based on pharmacokinetic characteristics such as clearance half-life and concentration-time distribution

Therefore, new therapeutic strategies to suppress drug resistance and improve the response to 5-FU are urgently needed