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Significantly, a major challenge currently lies in the selective targeting of lactylation without affecting other PTMs, as they are intricately linked and share a common set of regulatory enzymes, such as p300, HDACs, and Sirts, complicating the specific inhibition of lactylation
10.3390/ijms17020189 Int
(2020) 52:e13470
Endolysosomal proteases and their inhibitors in immunity
If regulatory submissions proceed as expected, the earliest plausible timeline for a market authorisation decision in the UK or Europe would be 2026 or 2027 though this is subject to the pace of regulatory review, the completeness of the submission package, and any additional data requests from the MHRA or EMA
These include better anemia, neurological symptoms, and Vitamin B12 levels in the blood
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