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Treatment arms Patients were randomized to RYBELSUS 14 mg (n=411) or Jardiance 25 mg (n=410), both once daily

While some can taper successfully and maintain their results, others require a consistent dose

Bacteria, colonic fermentation, and gastrointestinal health

Image adapted from: Saraiva, FK and Sposito, A

Peer review Peer review information Nature Metabolism thanks Florian Greten, Luisa Iommarini and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

All controlled studies referenced below were conducted in cell culture (3T3-L1 adipocytes, primary muscle stem cells) or rodent models (diet-induced obese mice, aged C57BL/6J mice)