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How much weight loss can I expect from metformin plus GLP-1 combination therapy
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To put that in perspective: if your therapeutic dose is 500 mcg, you'd theoretically need 500,000 mcg (500 mg) to approach potentially toxic levels
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Concerning data from semaglutide trials showed substantially less fat loss than predicted, indicating greater lean mass loss than expected
This extension not only increased the molecular weight (from 7.6 kDa to 9.1 kDa), but also reduced the affinity for IGF binding proteins (IGFBPs) through steric hindrance effect
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