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Specific abnormalities were observed for different classes of POPs
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GPX4, glutathione synthesis gene -glutamylcysteine synthase (GCS), GCLC, GCLM, and SLC7A11 are known targets of NRF2 [98, 105,106,107]
Beyond blood pressure control, clonidine has diverse off-label applications, including management of attention-deficit/hyperactivity disorder (ADHD), Tourette syndromeassociated tics, and autonomic hyperactivity during opioid, alcohol, and nicotine withdrawal
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