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Our clinical mantra is cautious curiosity: we are curious enough to try new tools, but cautious enough to prioritize safety, transparency, and measurable goals
doi: 10.1093/rheumatology/keaa395 268 PiaoXZhouJHuJ
PMID 23631642
In obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and lowering NAD+ availability [2]
Amcenestrant showed potential efficacy in combination with cyclin-dependent kinases (CDK) 4/6 inhibitors for advanced HR+ breast cancer
It lowers blood pressure and reduces the hearts workload, which helps prevent heart attacks and strokes
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