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The Lancet (2021) This Phase 2 dose-finding trial randomized adults with overweight or obesity without diabetes to cagrilintide at doses from 0.3 to 4.5 mg weekly, placebo, or liraglutide 3.0 mg daily as an active comparator across 57 sites in 10 countries

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central ER signaling might be modulating the actions of GLP-1 on food-reward behavior (Richard et al., 2016)