March 25, 2026 Wegovy and NAION Risk A new safety signal is emerging with the GLP1 drugs, and it is not a small one
Mice were split in 4 groups and received PBS, CA7S (100 mg/kg), sitagliptin, or CA7S (100 mg/kg) + sitagliptin
Fatigue sometimes from caloric reduction itself rather than the drug
Injecting into lipohypertrophic tissue reduces drug absorption, creating unpredictable pharmacokinetics that undermine the very stability microdosing aims to achieve
Many people start to see symptom improvements within 1 to 2 weeks, but full effects may take up to 6 to 8 weeks
[43] Hypothyroidism has been associated with altered ovulatory function, subfertility (the inability to conceive), menstrual irregularities, and higher miscarriage rates